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Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer.

Cytokine - 1 May 2009

Hamacher Rainer, Diersch Sandra, Scheibel Melanie, Eckel Florian, Mayr Martina, Rad Roland, Bajbouj Monther, Schmid Roland M, Saur Dieter, Schneider Günter

Abstract excerpt

Epidemiological and experimental data demonstrate, that inflammation contributes significantly to pancreatic carcinogenesis. IL1beta, a pleiotropic cytokine produced by inflammatory cells and tumor cells, promotes cancer progression. Single nucleotide polymorphisms (SNPs) of the IL1beta promoter were found to be associated with an increased risk for certain cancers. In this case-control study we determined...

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PMID: 19251436
DOI: 10.1016/j.cyto.2009.01.005

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