Article
Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus.
PloS one - 1 Jan 2011
Lannergård Jonas, Cao Sha, Norström Tobias, Delgado Alejandro, Gustafson John E, Hughes Diarmaid
Abstract excerpt
FusE mutants are fusidic acid-resistant small colony variants (SCVs) of Staphylococcus aureus that can be selected with aminoglycosides. All FusE SCVs have mutations in rplF, encoding ribosomal protein L6. However, individual FusE mutants including some with the same mutation in rplF display auxotrophy for either hemin or menadione, suggesting that additional mutations are involved. Here we show that FusE SCVs...
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