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Characterization of global patterns and the genetics of fusidic acid resistance.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2011

Farrell David J, Castanheira Mariana, Chopra Ian

Abstract excerpt

Fusidic acid binds to elongation factor G (EF-G), preventing its release from the ribosome, thus stalling bacterial protein synthesis. In staphylococci, high-level fusidic acid resistance is usually caused by mutations in the gene encoding EF-G, fusA, and low-level resistance is generally caused by the horizontally transferable mechanisms fusB and fusC that have a putative protective role on EF-G. In addition,...

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PMID: 21546625
DOI: 10.1093/cid/cir164

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