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Article

Diverse roles of Eph/ephrin signaling in the mouse lens.

PloS one - 1 Jan 2011

Cheng Catherine, Gong Xiaohua

Abstract excerpt

Recent genetic studies show that the Eph/ephrin bidirectional signaling pathway is associated with both congenital and age-related cataracts in mice and humans. We have investigated the molecular mechanisms of cataractogenesis and the roles of ephrin-A5 and EphA2 in the lens. Ephrin-A5 knockout ⁻/⁻ mice often display anterior polar cataracts while EphA2⁻/⁻ lenses show very mild cortical or nuclear cataracts at...

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Identifiers

PMID: 22140528
DOI: 10.1371/journal.pone.0028147
PMCID: PMC3226676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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