Article
EPHA2 is associated with age-related cortical cataract in mice and humans.
PLoS genetics - 1 Jul 2009
Jun Gyungah, Guo Hong, Klein Barbara E K, Klein Ronald, Wang Jie Jin, Mitchell Paul, Miao Hui, Lee Kristine E, Joshi Tripti, Buck Matthias, Chugha Preeti, Bardenstein David, Klein Alison P, Bailey-Wilson Joan E, Gong Xiaohua, Spector Tim D, Andrew Toby, Hammond Christopher J, Elston Robert C, Iyengar Sudha K, Wang Bingcheng
Abstract excerpt
Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination revealed development...
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