Article
A knockout mutation of a constitutive GPCR in Tetrahymena decreases both G-protein activity and chemoattraction.
PloS one - 1 Jan 2011
Lampert Thomas J, Coleman Kevin D, Hennessey Todd M
Abstract excerpt
Although G-protein coupled receptors (GPCRs) are a common element in many chemosensory transduction pathways in eukaryotic cells, no GPCR or regulated G-protein activity has yet been shown in any ciliate. To study the possible role for a GPCR in the chemoresponses of the ciliate Tetrahymena, we have generated a number of macronuclear gene knockouts of putative GPCRs found in the Tetrahymena Genome database. One...
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