Article
Mutations in genes encoding inner arm dynein heavy chains in Tetrahymena thermophila lead to axonemal hypersensitivity to Ca2+.
Cell motility and the cytoskeleton - 1 Nov 2005
Liu Siming, Hennessey Todd, Rankin Scott, Pennock David G
Abstract excerpt
Calcium-dependent ciliary reversals are seen in ciliated protozoans such as Tetrahymena in response to depolarizing stimuli, but the axonemal mechanisms responsible for this response are not well understood. The model is that the outer arm dyneins (OADs) control the beating frequency while the inner arm dyneins (IADs) regulate ciliary waveform. Since ciliary reversal is a type of waveform change, the model would...
Topics
- Animals
- Calcium
- Calcium Signaling
- Cell Culture Techniques
- Cilia
- Dyneins
- Movement
- Mutation
- Protozoan Proteins
- Tetrahymena thermophila
