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ParameciumBBS genes are key to presence of channels in Cilia

3 Sept 2012

Abstract excerpt

BACKGROUND: Changes in genes coding for ciliary proteins contribute to complex human syndromes called ciliopathies, such as Bardet-Biedl Syndrome (BBS). We used the model organism Paramecium to focus on ciliary ion channels that affect the beat form and sensory function of motile cilia and evaluate the effects of perturbing BBS proteins on these channels. METHODS: We used immunoprecipitations and mass...

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PMID: 23351336
DOI: 10.1186/2046-2530-1-16

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