UBE2C contributes to malignant phenotypes in clear cell renal cell carcinoma via cell cycle and apoptosis regulation.

doi:10.7717/peerj.21436

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

UBE2C contributes to malignant phenotypes in clear cell renal cell carcinoma via cell cycle and apoptosis regulation.

PeerJ - 1 Jan 2026

Qin Tianzi, Liang Jie, Ya Wentong, Long Yi, Wu Jichao, Meng Dongdong, Gan Fu

Abstract excerpt

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by aggressive behavior and poor prognosis. Ubiquitin-conjugating enzyme E2C (UBE2C), a key component of the ubiquitin-proteasome system, has been implicated in tumorigenesis; however, its role in ccRCC remains unclear. This study aimed to systematically investigate the clinical relevance, genetic associations, and biological functions of UBE2C...

Topics

Humans
Ubiquitin-Conjugating Enzymes
Carcinoma, Renal Cell
Apoptosis
Kidney Neoplasms
Cell Cycle
Animals
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Prognosis

Cell Proliferation

Mice

Up-Regulation

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 42333228
DOI: 10.7717/peerj.21436
PMCID: PMC13283363

Genes

UBE2C
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UBE2C contributes to malignant phenotypes in clear cell renal cell carcinoma via cell cycle and apoptosis regulation.PMID 42333228Read ↗

Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying UBE2C correlates to infiltration of regulatory T cellsSemantic proximity Read ↗

MiR-182-5p Inhibits the Tumorigenesis of clear cell renal cell carcinoma by Repressing UBE2TSemantic proximity Read ↗

Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

The tumor promoter role and molecular mechanism of C8orf76/CALB2 axis in clear cell renal cell carcinomaSemantic proximity Read ↗

FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma.Semantic proximity Read ↗

CDCA5 is a potent therapeutic target of clear cell renal cell carcinomaSemantic proximity Read ↗

KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathwaySemantic proximity Read ↗

Characterization of a G2M checkpoint-related gene model and subtypes associated with immunotherapy response for clear cell renal cell carcinomaSemantic proximity Read ↗

Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR‑4429/UBE2C axisSemantic proximity Read ↗

Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1Semantic proximity Read ↗

Loss of CDCA5 Promotes Cell Apoptosis by Activating the DNA Damage Response in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Downregulation of ENPP4 Is Associated with Poor Prognosis and Enhanced Malignant Phenotypes in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.