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Article

UBE2C contributes to malignant phenotypes in clear cell renal cell carcinoma via cell cycle and apoptosis regulation.

PeerJ - 1 Jan 2026

Qin Tianzi, Liang Jie, Ya Wentong, Long Yi, Wu Jichao, Meng Dongdong, Gan Fu

Abstract excerpt

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by aggressive behavior and poor prognosis. Ubiquitin-conjugating enzyme E2C (UBE2C), a key component of the ubiquitin-proteasome system, has been implicated in tumorigenesis; however, its role in ccRCC remains unclear. This study aimed to systematically investigate the clinical relevance, genetic associations, and biological functions of UBE2C...

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Topics

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Share to Apoptosis
Share to Carcinoma, Renal Cell
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to Kidney Neoplasms

Share to Ubiquitin-Conjugating Enzymes

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Source

Open in PubMed Open full text

Identifiers

PMID: 42333228
DOI: 10.7717/peerj.21436
PMCID: PMC13283363

Genes

UBE2C
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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