Article
A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Mar 2004
Rudofsky G, Isermann B, Schilling T, Schiekofer S, Andrassy M, Schneider J G, Morcos M, Humpert P M, Sayed A A R, Witte S, Renn W, Pfohl M, Hamann A, Nosikov V, Schleicher E, Häring H-U, Rudofsky G, Ritz E, Nawroth P P, Bierhaus A
Abstract excerpt
Several polymorphisms have been identified in the RAGE-promoter region that might modulate the outcome of disease. Here we analyse the association of a 63bp deletion (delta63) spanning from bp - 407 to bp - 345 with diabetic nephropathy. The deletion was determined using the polymerase chain reaction (PCR) in a cross-sectional study with 1087 patients with type 1 diabetes (n = 559) and type 2 diabetes (n = 528)....
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