A genome-wide analysis reveals that the Drosophila transcription factor Lola promotes axon growth in part by suppressing expression of the actin nucleation factor Spire.

Abstract excerpt

BACKGROUND: The phylogenetically conserved transcription factor Lola is essential for many aspects of axon growth and guidance, synapse formation and neural circuit development in Drosophila. To date it has been difficult, however, to obtain an overall view of Lola functions and mechanisms. RESULTS: We use expression microarrays to identify the lola-dependent transcriptome in the Drosophila embryo. We find that...

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