Article
Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.
The Journal of pharmacology and experimental therapeutics - 1 Mar 2012
Zhu Gang, Yoshida Shukuko, Migita Keisuke, Yamada Junko, Mori Fumiaki, Tomiyama Masahiko, Wakabayashi Koichi, Kanematsu Takashi, Hirata Masato, Kaneko Sunao, Ueno Shinya, Okada Motohiro
Abstract excerpt
Phospholipase C-related, but catalytically inactive protein (PRIP) was first identified as a novel inositol 1,4,5-triphosphate binding protein. The PRIP-1 subtype is expressed predominantly in the central nervous system and binds directly to the GABA type A receptor (GABA(A)-R) β-subunit and several other proteins involved in the trafficking of GABA(A)-Rs to the plasma membrane. We found that the PRIP-1 knockout...
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