Article
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.
American journal of human genetics - 9 Sept 2011
Bhatia Gaurav, Patterson Nick, Pasaniuc Bogdan, Zaitlen Noah, Genovese Giulio, Pollack Samuela, Mallick Swapan, Myers Simon, Tandon Arti, Spencer Chris, Palmer Cameron D, Adeyemo Adebowale A, Akylbekova Ermeg L, Cupples L Adrienne, Divers Jasmin, Fornage Myriam, Kao W H Linda, Lange Leslie, Li Mingyao, Musani Solomon, Mychaleckyj Josyf C, Ogunniyi Adesola, Papanicolaou George, Rotimi Charles N, Rotter Jerome I, Ruczinski Ingo, Salako Babatunde, Siscovick David S, Tayo Bamidele O, Yang Qiong, McCarroll Steve, Sabeti Pardis, Lettre Guillaume, De Jager Phil, Hirschhorn Joel, Zhu Xiaofeng, Cooper Richard, Reich David, Wilson James G, Price Alkes L
Abstract excerpt
The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the increase in beneficial alleles and plays a role in explaining diversity across human populations. By discovering traits subject to positive selection, we can better understand the population level response to environmental pressures including infectious...
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