Article
Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden.
Annals of the rheumatic diseases - 1 Jun 2012
Ärlestig Lisbeth, Mullazehi Mohammed, Kokkonen Heidi, Rocklöv Joacim, Rönnelid Johan, Dahlqvist Solbritt Rantapää
Abstract excerpt
BACKGROUND: Rheumatoid factors (RFs) and antibodies against cyclic citrullinated peptides (CCPs) of IgG, IgA and IgM isotype have been shown to precede disease onset by years. OBJECTIVE: To evaluate serological risk markers in first-degree relatives from multicase families in relation to genetic and environmental risk factors. METHODS: 51 multicase families consisting of 163 individuals with rheumatoid arthritis...
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