Post-translational polymorphism of human IgA identified by immunoisoelectrofocusing.

doi:10.1111/j.1744-313x.1990.tb00858.x

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Article

Post-translational polymorphism of human IgA identified by immunoisoelectrofocusing.

Journal of immunogenetics - 1 Jan 2000

De Benedictis G, Rose G, Brancati C

Abstract excerpt

Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S. The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment. It can be postulated, therefore, that S encodes a sialyltransferase which attaches sialic acid at the outer prosthetic chains of IgA.

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