Article
Contribution of germ line BRCA2 sequence alterations to risk of familial esophageal cancer in a high-risk area of India.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2010
Kaushal M, Chattopadhyay I, Phukan R, Purkayastha J, Mahanta J, Kapur S, Saxena S
Abstract excerpt
The incidence of esophageal squamous cell carcinoma (ESCC) is very high in the northeast region of India. An earlier study from China and Iran suggested that mutations in BRCA2 gene may play a role in the etiology of familial ESCC. However, the frequency of BRCA2 gene germ line mutations and its contribution to risk of familial aggregation of ESCC in high-risk region of India are not known. In the current study...
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