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Article

Effect of co-inheritance of β-thalassemia and hemochromatosis mutations on iron overload.

Hemoglobin - 1 Jan 2012

López-Escribano Herminio, Ferragut Joana F, Parera Maria M, Guix Pilar, Castro José A, Ramon M Misericòrdia, Picornell Antònia

Abstract excerpt

Co-inheritance of mutations in the HFE gene underlying hereditary hemocromatosis (HH) may play a role in the variability of iron status in patients with β-thalassemia (β-thal) minor. Different studies have yielded conflicting results: some suggest iron overload might arise from the interaction of the β-thal trait with homozygosity or even heterozygosity for HFE mutations and others that it was unrelated to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22122796
DOI: 10.3109/03630269.2011.637148

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of co-inheritance of β-thalassemia and hemochromatosis mutations on iron overload.PMID 22122796Read ↗

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Haemochromatosis in patients with β‐thalassaemia traitSemantic proximity Read ↗

HFE gene mutations in Brazilian thalassemic patients.Semantic proximity Read ↗

Investigation of correlation between H63D and C282Y mutations in HFE gene and serum Ferritin level in beta-thalassemia major patients.Semantic proximity Read ↗

HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions.Semantic proximity Read ↗

Effect of the Hemochromatosis Mutations on Iron Overload among the Indian β Thalassemia Carriers.Semantic proximity Read ↗

Role of HFE gene mutations on developing iron overload in beta-thalassaemia carriers in Egypt.Semantic proximity Read ↗

Serum ferritin and transferrin saturation levels in β⁰ and β(+) thalassemia patients.Semantic proximity Read ↗

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