Article
The influence of hemochromatosis mutations on iron overload of thalassemia major.
Haematologica - 1 Sept 1999
Longo F, Zecchina G, Sbaiz L, Fischer R, Piga A, Camaschella C
Abstract excerpt
BACKGROUND AND OBJECTIVE: Hemochromatosis is a genetic form of iron overload due to a defective HFE gene. Secondary iron overload is the main complication in transfusion-dependent thalassemia patients. In this work we have examined the prevalence of HFE mutations in thalassemia major and evaluated the degree of iron overload of patients with and without HFE mutations. DESIGN AND METHODS: HFE mutations were...
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