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Article

HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions.

Indian journal of pathology & microbiology - 1 Jan 2007

Sharma Vineeta, Panigrahi Inusha, Dutta Pankhi, Tyagi Seema, Choudhry Ved Prakash, Saxena Renu

Abstract excerpt

Iron overload is a well-documented complication in thalassemia intermedia. Moreover, it is seen that the number of blood transfusions received does not correlate with the degree of overload. Since, HFE gene is associated with iron overload; the present study was conducted in an attempt to evaluat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17474269

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17474269-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions.PMID 17474269Read ↗

Investigation of correlation between H63D and C282Y mutations in HFE gene and serum Ferritin level in beta-thalassemia major patients.Semantic proximity Read ↗

Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron OverloadSemantic proximity Read ↗

The role of HFE mutations on iron metabolism in beta-thalassemia carriers.Semantic proximity Read ↗

The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls.Semantic proximity Read ↗

Role of HFE gene mutations on developing iron overload in beta-thalassaemia carriers in Egypt.Semantic proximity Read ↗

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Determination of mutations in iron regulating genes of beta thalassemia major patients of Khyber Pakhtunkhwa, PakistanSemantic proximity Read ↗

Effect of the Hemochromatosis Mutations on Iron Overload among the Indian β Thalassemia Carriers.Semantic proximity Read ↗

Individuals homozygous for the H63D mutation have significantly elevated iron indexes.Semantic proximity Read ↗

The influence of hemochromatosis mutations on iron overload of thalassemia major.Semantic proximity Read ↗

Association of HFE Gene Mutations With Serum Ferritin Level and Heart and Liver Iron Overload in Patients With Transfusion-dependent Beta-Thalassemia.Semantic proximity Read ↗

H63D homozygotes with hyperferritinaemia: Is this genotype, the primary cause of iron overload?Semantic proximity Read ↗

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