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Article

Influence of matrix metalloproteinase-12 on fibrinogen level.

Atherosclerosis - 1 Feb 2012

Motterle Anna, Xiao Qingzhong, Kiechl Stefan, Pender Sylvia L F, Morris Gareth E, Willeit Johann, Caulfield Mark J, Ye Shu

Abstract excerpt

In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction. In this study, we found that mean plasma fibrinogen level was approximately 10-fold higher in MMP12 knockout mice than wildtype mice (p=0.0006). Differential allelic expression analysis of human MMP12 gene polymorphism...

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Source

Identifiers

PMID: 22119538
DOI: 10.1016/j.atherosclerosis.2011.11.003

Genes

MMP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Influence of matrix metalloproteinase-12 on fibrinogen level.PMID 22119538Read ↗

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