Article
Role of -675 4G/5G in the plasminogen activator inhibitor-1 gene and -308G/A tumor necrosis factor-α gene polymorphisms in obese Argentinean patients.
Genetic testing and molecular biomarkers - 1 May 2012
Wingeyer Silvia D Perés, Graffigna Mabel N, Belli Susana H, Benetucci Jorge, de Larrañaga Gabriela F
Abstract excerpt
AIM: Plasminogen activator inhibitor-1 (PAI-1) and tumor necrosis factor-α (TNF-α) are increased in the circulation of obese persons. Because a direct link between PAI-1 and TNF-α in obesity has been observed, they are candidate genes for the development of obesity. We sought to evaluate the relation between the genotypic and allelic frequencies of the -675 4G/5G PAI-1 and -308 G/A TNF-α polymorphisms and their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.