Transgenic Mice Expressing Human Transferrin as a Model for Meningococcal Infection

Abstract excerpt

The pathogenesis of meningococcal disease is poorly understood due to the lack of a relevant animal model. Moreover, the use of animal models is not optimal as most meningococcal virulence determinants recognize receptors that are specifically expressed in human tissues. One major element of the host specificity is the system of meningococcal iron uptake by transferrin-binding proteins that bind specifically...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amoebic Infections and Treatments
• Share to Bacterial Genetics and Biotechnology
• Share to Bacterial Infections and Vaccines