Article
Qilin is essential for cilia assembly and normal kidney development in zebrafish.
PloS one - 1 Jan 2011
Li Jade, Sun Zhaoxia
Abstract excerpt
Defects in the cilium, a once thought vestigial organelle, have recently been implicated in many human diseases, including a number of cystic kidney diseases such as polycystic kidney disease (PKD), Bardet Bieldl Syndrome, and Meckel-Gruber Syndrome. In a forward genetic screen, qilin was identified as a novel gene important in the pathogenesis of kidney cysts in zebrafish. In this paper we characterized...
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