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Mast cell disorders: From infancy to maturity

3 Nov 2018

Abstract excerpt

Mast cells are typically linked to immediate hypersensitivity and anaphylaxis. This review looks beyond this narrow role, focusing on how these cells have evolved and diversified via natural selection promoting serine protease gene duplication, augmenting their innate host defense function against helminths and snake envenomation. Plasticity of mast cell genes has come at a price. Somatic activating mutations in...

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PMID: 30390314
DOI: 10.1111/all.13657

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