Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations.

Abstract excerpt

Clustered mutations may be broadly defined as the presence of two or more mutations within a spatially localized genomic region on a single chromosome. Known instances vary in terms of both the number and type of the component mutations, ranging from two closely spaced point mutations to tens or even hundreds of genomic rearrangements. Although clustered mutations can represent the observable net result of...

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