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Article

Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage.

Biochemical and biophysical research communications - 9 Dec 2011

Jarem Daniel A, Delaney Sarah

Abstract excerpt

The expansion of a CAG trinucleotide repeat (TNR) sequence has been linked to several neurological disorders, for example, Huntington's disease (HD). In HD, healthy individuals have 5-35 CAG repeats. Those with 36-39 repeats have the premutation allele, which is known to be prone to expansion. In the disease state, greater than 40 repeats are present. Interestingly, the formation of non-B DNA conformations by the...

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Identifiers

PMID: 22100810
DOI: 10.1016/j.bbrc.2011.11.013
PMCID: PMC3237924

Genes

TNR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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