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Article

Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases.

Nucleic acids research - 1 Jun 1996

Petruska J, Arnheim N, Goodman M F

Abstract excerpt

Expansions of trinucleotide repeats in DNA, a novel source of mutations associated with human disease, may arise by DNA replication slippage initiated by hairpin folding of primer or template strands containing such repeats. To evaluate the stability of single-strand folding by repeating triplets of DNA bases, thermal melting profiles of (CAG)10, (CTG)10, (GAC)10 and (GTC)10 strands are determined at low and...

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Identifiers

PMID: 8668527
DOI: 10.1093/nar/24.11.1992
PMCID: PMC145917

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