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Drug-Permeability and Transporter Assays in Caco-2 and Mdck Cell Lines

18 Nov 2011

Abstract excerpt

The human colon adenocarcinoma Caco-2 and Madin-Darby canine kidney epithelial cell lines provide in vitro tools to assess a drug's permeability and transporter interactions during discovery and development. The cells, when cultured on semiporous filters, form confluent monolayers that model the intestinal epithelial barrier for permeability, transporter and drug-interaction assays. The applications of these...

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PMID: 22098353
DOI: 10.4155/fmc.11.149

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