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Article

Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissue.

Biopharmaceutics & drug disposition - 1 Mar 2017

Brück S, Strohmeier J, Busch D, Drozdzik M, Oswald S

Abstract excerpt

BACKGROUND: Induction or inhibition of drug transporting proteins by concomitantly administered drugs can cause serious drug-drug interactions (DDIs). However, in vitro assays currently available are mostly for studying the inhibitory potential of drugs on intestinal transporter proteins, rather than induction. Therefore, this study investigated the suitability of the frequently used intestinal Caco-2 cell line...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Liquid

Share to Intestinal Mucosa

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Source

Identifiers

PMID: 27516347
DOI: 10.1002/bdd.2025

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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