Comparison of Drug Transporter Levels in Normal Colon, Colon Cancer, and Caco-2 Cells:  Impact on Drug Disposition and Discovery

Abstract excerpt

A critical step in early phase drug development is the determination of oral bioavailability. In part, the ability to predict whether a drug will be effectively transported across the gastrointestinal mucosa can be estimated from the physicochemical properties of the compound. Although advancements through rational drug design have more correctly predicted bioavailability, considerable variability remains to be...

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