Article
A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.
PloS one - 1 Jan 2011
Zuo Lingjun, Zhang Clarence K, Wang Fei, Li Chiang-Shan R, Zhao Hongyu, Lu Lingeng, Zhang Xiang-Yang, Lu Lin, Zhang Heping, Zhang Fengyu, Krystal John H, Luo Xingguang
Abstract excerpt
Several genome-wide association studies (GWASs) reported tens of risk genes for alcohol dependence, but most of them have not been replicated or confirmed by functional studies. The present study used a GWAS to search for novel, functional and replicable risk gene regions for alcohol dependence. Associations of all top-ranked SNPs identified in a discovery sample of 681 African-American (AA) cases with alcohol...
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