Article
Acrylamide exposure induces a delayed unscheduled DNA synthesis in germ cells of male mice that is correlated with the temporal pattern of adduct formation in testis DNA.
Environmental and molecular mutagenesis - 1 Jan 1990
Sega G A, Generoso E E, Brimer P A
Abstract excerpt
A study of meiotic and postmeiotic germ-cell-stage sensitivity of male mice to induction of unscheduled DNA synthesis (UDS) by acrylamide showed that DNA repair could be detected in early spermatocytes (after the last scheduled DNA synthesis) through about mid-spermatid stages. No DNA repair could be detected in later stages. The maximum UDS response was observed 6 hr after i.p. exposure and was about 5 times...
Topics
- Acrylamide
- Acrylamides
- Animals
- Carbon Radioisotopes
- DNA
- DNA Repair
- Liver
- Male
- Mice
- Mice, Inbred C3H
- Mutation
- Spermatogenesis