Article
Pneumococcal sequence type replacement among American Indian children: a comparison of pre- and routine-PCV7 eras.
Vaccine - 16 Mar 2012
Scott Jennifer R, Hanage William P, Lipsitch Marc, Millar Eugene V, Moulton Lawrence H, Hinds Jason, Reid Raymond, Santosham Mathuram, O'Brien Katherine L
Abstract excerpt
BACKGROUND: Multi-locus sequence typing (MLST) of pneumococcal isolates collected during an efficacy trial of the 7-valent pneumococcal conjugate vaccine (PCV7) among Navajo and White Mountain Apache children from 1998 to 2000 showed a non-differential expansion of pre-existing sequence types (STs) and only one capsule-switching event in the PCV7-randomized communities. PCV7 was introduced as a routine infant...
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