Article
Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine.
The Journal of infectious diseases - 15 Oct 2007
Lipsitch Marc, O'Neill Keith, Cordy Derrick, Bugalter Boris, Trzcinski Krzysztof, Thompson Claudette M, Goldstein Richard, Pelton Stephen, Huot Heather, Bouchet Valerie, Reid Raymond, Santosham Mathuram, O'Brien Katherine L
Abstract excerpt
Widespread use of 7-valent pneumococcal conjugate vaccine (PCV7) has led to significant reductions in disease while changing pneumococcal population dynamics via herd immunity and serotype replacement. We performed multilocus sequence typing (MLST) on 590 pneumococcal isolates obtained during the American Indian clinical trial of PCV7, in which communities were randomized for eligible children to receive either...
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