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MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

28 Aug 2019

Abstract excerpt

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM)...

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PMID: 31466240
DOI: 10.3390/cells8090991

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