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Article

Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease.

Proteins - 15 Feb 2008

Altman Michael D, Nalivaika Ellen A, Prabu-Jeyabalan Moses, Schiffer Celia A, Tidor Bruce

Abstract excerpt

Drug resistance in HIV-1 protease, a barrier to effective treatment, is generally caused by mutations in the enzyme that disrupt inhibitor binding but still allow for substrate processing. Structural studies with mutant, inactive enzyme, have provided detailed information regarding how the substrates bind to the protease yet avoid resistance mutations; insights obtained inform the development of next generation...

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Identifiers

PMID: 17729291
DOI: 10.1002/prot.21514
PMCID: PMC2802840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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