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Article

Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of hepatitis C virus.

The Journal of biological chemistry - 2 Jan 2012

Herod Morgan R, Jones Daniel M, McLauchlan John, McCormick Christopher J

Abstract excerpt

In hepatitis C virus, non-structural proteins are cleaved from the viral polyprotein by viral encoded proteases. Although proteolytic processing goes to completion, the rate of cleavage differs between different boundaries, primarily due to the sequence at these positions. However, it is not known whether slow cleavage is important for viral replication or a consequence of restrictions on sequences that can be...

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Identifiers

PMID: 22084249
DOI: 10.1074/jbc.M111.311407
PMCID: PMC3249110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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