Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted therapies: how personal should we go?

Nature reviews. Clinical oncology - 15 Nov 2011

Martini Miriam, Vecchione Loredana, Siena Salvatore, Tejpar Sabine, Bardelli Alberto

Abstract excerpt

Despite the development of drugs inhibiting the oncogenic proteins that cancer cells are dependent on, attempts to match targeted therapies to the genetic makeup of individual tumors is proving more difficult than expected. Until now, the paradigm has been a binary correlation between a mutated cancer gene and response to a given therapy. However, recent evidence indicates that different genetic alterations, such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic
Share to EGFR gene
Share to KRAS gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Mutation

Share to Neoplasm Proteins

Share to Neoplasms

Share to Precision Medicine

Source

Identifiers

PMID: 22083042
DOI: 10.1038/nrclinonc.2011.164

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted therapies: how personal should we go?PMID 22083042Read ↗

Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer.Semantic proximity Read ↗

Personalised cancer medicine.Semantic proximity Read ↗

Linking somatic genetic alterations in cancer to therapeutics.Semantic proximity Read ↗

Mechanism of EGER-related cancer drug resistance.Semantic proximity Read ↗

[Genetic alterations and chemoresistance].Semantic proximity Read ↗

Hotspot oncomutations: implications for personalized cancer treatment.Semantic proximity Read ↗

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancerSemantic proximity Read ↗

Does EGFR targeted therapy change the natural history of EGFR mutant status?Semantic proximity Read ↗

Genetic Interactions and Tissue Specificity Modulate the Association of Mutations with Drug Response.Semantic proximity Read ↗

Kinase mutations in cancer: chinks in the enemy's armour?Semantic proximity Read ↗

BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications.Semantic proximity Read ↗

Evolutionary dynamics and significance of multiple subclonal mutations in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.