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Article

Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases.

Journal of the American Chemical Society - 21 Dec 2011

Mueller Jonathan W, Link Nina M, Matena Anja, Hoppstock Lukas, Rüppel Alma, Bayer Peter, Blankenfeldt Wulf

Abstract excerpt

Parvulins compose a family of small peptidyl-prolyl isomerases (PPIases) involved in protein folding and protein quality control. A number of amino acids in the catalytic cavity are highly conserved, but their precise role within the catalytic mechanism is unknown. The 0.8 Å crystal structure of the prolyl isomerase domain of parvulin Par14 shows the electron density of hydrogen atoms between the D74, H42, H123,...

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Identifiers

PMID: 22081960
DOI: 10.1021/ja2086195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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