Article
The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis.
Molecules and cells - 1 Dec 2011
Kim Su Na, Shim Hyun Pyo, Jeon Bu-Nam, Choi Won-Il, Hur Man-Wook, Girton Jack R, Kim Sang Hee, Jeon Sang-Hak
Abstract excerpt
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to...
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