Article
The Drosophila pleiohomeotic mutation enhances the Polycomblike and Polycomb mutant phenotypes during embryogenesis and in the adult.
The International journal of developmental biology - 1 Sept 2003
Kwon Seung-Hae, Kim Sang Hee, Chung Hae-Moon, Girton Jack R, Jeon Sang-Hak
Abstract excerpt
In Drosophila, the spatially restricted expression of the homeotic genes is controlled by Polycomb group (PcG) repression. PcG proteins appear to form different complexes to repress this gene expression. Although the pleiohomeotic gene (pho) shares mutational phenotypes with other PcG mutations, which demonstrates that PHO binds directly with a Polycomb (Pc)-containing complex, the genetic interactions of pho...
Topics
- Animals
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Extremities
- Limb Deformities, Congenital
- Male
- Mutation
- Phenotype
- Polycomb Repressive Complex 1
- Polycomb-Group Proteins