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Article

Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice.

The European journal of neuroscience - 1 Jan 2011

Procaccini Chiara, Aitta-aho Teemu, Jaako-Movits Külli, Zharkovsky Alexander, Panhelainen Anne, Sprengel Rolf, Linden Anni-Maija, Korpi Esa R

Abstract excerpt

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit-deficient (GluA1-/-) mice display novelty-induced hyperactivity, cognitive and social defects and may model psychiatric disorders, such as schizophrenia and depression/mania. We used c-Fos expression in GluA1-/- mice to identify brain regions responsible for novelty-induced hyperlocomotion. Exposure to a novel cage for 2 h...

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PMID: 21073553
DOI: 10.1111/j.1460-9568.2010.07485.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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