Article
Expression profiling of non-aflatoxigenic Aspergillus parasiticus mutants obtained by 5-azacytosine treatment or serial mycelial transfer.
Toxins - 1 Aug 2011
Wilkinson Jeffrey R, Kale Shubha P, Bhatnagar Deepak, Yu Jiujiang, Ehrlich Kenneth C
Abstract excerpt
Aflatoxins are carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Previous studies found that repeated serial mycelial transfer or treatment of A. parasiticus with 5-azacytidine produced colonies with a fluffy phenotype and inability to produce aflatoxins. To understand how these treatments affect expression of genes involved in aflatoxin production and...
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