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Article

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations.

PloS one - 1 Jan 2011

Lua Shixiong, Qin Haina, Lim Liangzhong, Shi Jiahai, Gupta Garvita, Song Jianxing

Abstract excerpt

T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the structure, stability, dynamics and binding capacity of the T46I-MSP domain. The results reveal: 1) unlike P56S which we previously showed to completely eliminate the...

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PMID: 22069488
DOI: 10.1371/journal.pone.0027072
PMCID: PMC3206076

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