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Article

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy.

Journal of lipid research - 1 Jan 2013

Georgiadou Dimitra, Stamatakis Kostas, Efthimiadou Eleni K, Kordas George, Gantz Donald, Chroni Angeliki, Stratikos Efstratios

Abstract excerpt

Lipoprotein glomerulopathy (LPG) is a dominant inherited kidney disorder characterized by lipoprotein thrombi in glomerular capillaries. Single-amino-acid mutations in apoE have been associated with the development of the disease, although the mechanism is unknown. In an effort to gain mechanistic insight linking the presence of such mutations and the development of LPG, we evaluated the effects of three of the...

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Identifiers

PMID: 23110818
DOI: 10.1194/jlr.M030965
PMCID: PMC3520522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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