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Article

Evidence against Cellular Internalization in Vivo of NMO-IgG, Aquaporin-4, and Excitatory Amino Acid Transporter 2 in Neuromyelitis Optica

9 Nov 2011

Abstract excerpt

Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are thought to be pathogenic in neuromyelitis optica (NMO). Prior work has suggested that a key component of NMO autoantibody (NMO-IgG) pathogenesis is internalization of AQP4 and the associated glutamate transporter EAAT2, leading to glutamate excitotoxicity. Here, we show selective endocytosis of NMO-IgG and AQP4 in transfected cell cultures, but...

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PMID: 22069320
DOI: 10.1074/jbc.m111.297275

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Click a neighbor to travelStep 1 · 12 closest

Evidence against Cellular Internalization in Vivo of NMO-IgG, Aquaporin-4, and Excitatory Amino Acid Transporter 2 in Neuromyelitis OpticaPMID 22069320Read ↗

Neuromyelitis optica (NMO)--an autoimmune disease of the central nervous system (CNS).Semantic proximity Read ↗

The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosisSemantic proximity Read ↗

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In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspringSemantic proximity Read ↗

NMO‐IgG: A Specific Biomarker for Neuromyelitis OpticaSemantic proximity Read ↗

Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding.Semantic proximity Read ↗

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Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders.Semantic proximity Read ↗

Potential Role of Antibodies against Aquaporin-1 in Patients with Central Nervous System Demyelination.Semantic proximity Read ↗

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