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Article

The IgE gene in primates exhibits extraordinary evolutionary diversity.

Immunogenetics - 1 Apr 2012

Wu Pheidias C, Chen Jiun-Bo, Kawamura Shoji, Roos Christian, Merker Stefan, Shih Chih-Chin, Hsu Ban-Dar, Lim Carmay, Chang Tse Wen

Abstract excerpt

Membrane-bound IgE (mIgE) on B lymphocytes is essential for IgE production. Earlier studies showed that the ε chain of mIgE (mε) on human B cells has a "long" isoform, with an extra "CεmX" domain of 52 amino acid (aa) residues between the CH4 domain and the membrane-anchor segment, as compared to the conventional "short" isoform. Because CεmX provides an antigenic site for targeting IgE-expressing B cells to...

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Identifiers

PMID: 22068888
DOI: 10.1007/s00251-011-0586-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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