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Article

The type I interferon system in the etiopathogenesis of autoimmune diseases

1 Nov 2011

Abstract excerpt

Many patients with systemic autoimmune diseases have signs of a continuous production of type I interferon (IFN) and display an increased expression of IFN-α-regulated genes. The reason for the on-going IFN-α synthesis in these patients seems to be an activation of plasmacytoid dendritic cells (pDCs) by immune complexes (ICs), consisting of autoantibodies in combination with DNA or RNA-containing autoantigens....

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PMID: 22066971
DOI: 10.3109/03009734.2011.624649

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