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Article

Direct observation of downhill folding of lambda-repressor in a microfluidic mixer.

Biophysical journal - 16 Sept 2009

DeCamp Stephen J, Naganathan Athi N, Waldauer Steven A, Bakajin Olgica, Lapidus Lisa J

Abstract excerpt

The protein lambda(6-85) has been implicated in barrierless folding by observations of kinetic relaxation after nanosecond T-jump. In this work we observed folding of this protein after dilution of a high denaturant in an ultrarapid microfluidic mixer at temperatures far below the thermal midpoint. The observations of total intensity and spectral shift of tryptophan fluorescence yielded distinctly different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19751683
DOI: 10.1016/j.bpj.2009.07.003
PMCID: PMC2749784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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