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Article

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature.

Cell research - 1 Jan 2012

Xu Huansheng, Yi B Alexander, Wu Hao, Bock Christoph, Gu Hongcang, Lui Kathy O, Park Joo-Hye C, Shao Ying, Riley Alyssa K, Domian Ibrahim J, Hu Erding, Willette Robert, Lepore John, Meissner Alexander, Wang Zhong, Chien Kenneth R

Abstract excerpt

Cardiomyocytes derived from pluripotent stem cells can be applied in drug testing, disease modeling and cell-based therapy. However, without procardiogenic growth factors, the efficiency of cardiomyogenesis from pluripotent stem cells is usually low and the resulting cardiomyocyte population is heterogeneous. Here, we demonstrate that induced pluripotent stem cells (iPSCs) can be derived from murine ventricular...

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Identifiers

PMID: 22064699
DOI: 10.1038/cr.2011.171
PMCID: PMC3351933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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